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ISSN (Print): 2359-4802 | ISSN (Online): 2359-5647



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EDITORIAL

Cardiology Journals from Portuguese-Speaking Countries: Challenges and Opportunities
Luiz Felipe P. Moreira






Scientific development is currently happening at an increasingly faster pace. With this situation, the scientific journals are required to commit to disseminating new knowledge with greater agility and broad propagation by the main international indexers. On the other hand, the mission of the scientific journals is also to encourage the propagation and discussion of new subjects in scientific communities, a situation of great importance mainly for those journals associated with medical societies and with a predominantly national circulation.

Keywords: Cardiovascular Diseases; Periodicals as Topic; Bibliometrics; Bilinguism.
VÍDEO 1
Check the interview with the author Dra. Christianne Scaramello talking about the article "Study of the Use of Dabigatran in Brazilian Public Hospital Specialized in Cardiology" published in the July and August/2017 issue.

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ORIGINAL ARTICLE

Probabilistic Model for Prediction of Prognostics in Myocardial Revascularization: Complications in Coronary Surgery
Valcellos José da Cruz Viana, Felipe Coelho Argolo, Nilzo Augusto Mendes Ribeiro, Augusto Ferreira da Silva Junior, Luis Claudio Lemos Correia

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ORIGINAL ARTICLE

Study of Dabigatran Use in a Brazilian Public Hospital Specialized in Cardiology
Luise Barros Martins, Ivis Levy Fernandes Martins, Raíssa Miranda Silva, Flávia Valéria dos Santos Almeida, Christianne Bretas Vieira Scaramello

VIDEO 2
Check out the interview of the IJCS editor-in-chief, Dr. Claudio Tinoco, on the topics addressed in the articles: "Challenges for Contemporary Medicine" and "C-Reactive Protein in Oral Contraceptive Users".

IJCS - International Journal of Cardiovascular Sciences
Edition: 30.4 - 12 Articles



EDITORIAL

Cardiology Journals from Portuguese-Speaking Countries: Challenges and Opportunities
Periódicos Cardiológicos de Países de Língua Portuguesa: Desafios e Oportunidades

Luiz Felipe P. Moreira
International Journal of Cardiovascular Sciences. 2017;30(4):283-284

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ORIGINAL ARTICLES

24-Hour Ambulatory Blood Pressure Monitoring Predicts Outcomes of Hypertensive Patients in Primary Care: A Cohort Study
A Monitorização Ambulatorial da Pressão Arterial de 24 Horas Prediz Desfechos em Hipertensos na Atenção Primária à Saúde: Estudo de Coorte

Guilherme Brasil Grezzana, Airton Tetelbon Stein, Lucia Campos Pellanda
International Journal of Cardiovascular Sciences. 2017;30(4):285-292

+   Abstract  
Background: Arterial hypertension is an important risk factor for cardiovascular outcomes. However, in most Primary Health Care centers, blood pressure remains at inadequate control levels. Ambulatory Blood Pressure Monitoring (ABPM) is a useful tool in predicting cardiovascular morbidity and mortality. The implementation of 24-hour ABPM and evaluation of cardiovascular outcomes in Primary Health Care may be effective in improving strategies for monitoring hypertensive patients in this setting.
Objective:> To evaluate uncontrolled arterial hypertension detected by 24-hour ABPM as a predictor of cardiovascular outcomes in hypertensive patients from Primary Health Care in a low-resource environment.
Methods: Cohort study based on primary health care centers. The study was carried out with 143 hypertensive patients, who underwent 24-hour ABPM at baseline. Therapeutic targets were based on the Eighth Joint National Committee, the Brazilian Hypertension Guideline, and the European Hypertension Guideline. Medical records of emergency care, hospital admissions, and death certificates were reviewed.
Results: The sample consisted of 143 patients who met the inclusion criteria. After 4 years of follow-up, there were 17 deaths, 12 new cases of atrial fibrillation and 37 hospital admissions related to cardiovascular outcomes. During the follow-up period, the 24-hour ABPM showed a predictive result for new cases of atrial fibrillation (p = 0.015) and a combination of cardiovascular outcomes, mortality, and hospital admissions (p = 0.012).
Conclusion: The 24-hour ABPM was an important predictor of cardiovascular outcomes in a hypertensive population that seeks assistance in Primary Health Care centers. (Int J Cardiovasc Sci. 2017;30(4):285-292)

Keywords: Blood Pressure Monitoring, Ambulatory; Hypertension/ complications; Public Health; Cardiovascular Diseases.

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Are Patients’ Blood Pressure Levels Being Routinely Measured in Medical Offices?
A Pressão Arterial dos Pacientes Está Sendo Medida Rotineiramente nos Consultórios Médicos?

Israel Guilharde Maynarde, Thiago Veiga Jardim, Weimar Kunz Sebba Barroso de Souza, Ana Luiza Lima Sousa, Andrey Rocha Rocca, Bruna Yana de Carvalho Lin, Natália Mirelle Carrijo dos Santos, Diogo Pereira Santos Sampaio, Xênia Larissa Motta Serafim, Paulo Cesar Brandao Veiga Jardim
International Journal of Cardiovascular Sciences. 2017;30(4):293-298

+   Abstract  
Background: Blood pressure measurement is recommended in all medical evaluations, regardless of the specialty. It is a simple and easy-to-do procedure, but usually neglected or performed incorrectly.
Objectives: To assess if blood pressure is being measured routinely and compare the values obtained in the usual ambulatory consultations to those obtained when following the adequate techniques.
Methods: Cross-sectional and observational study that included adult (age >18 years) outpatients treated in clinical and surgical specialties of a teaching hospital. Subjects answered a specific questionnaire and then three blood pressure measurements were performed according to the current guidelines by trained research staff. After that, the patients had their appointments and at the end, the medical charts were checked to see if blood pressure was measured and, if so, the observed value was recorded.
Results: We included 129 consecutive patients with a mean age of 53 years (± 15.92) predominantly females (61.2%). Most of the appointments occurred in clinical specialties (70.5%) and 49.6% reported themselves as hypertensive. Blood pressure was not measured in 38.8% of the patients, more frequently in surgical specialties (72,5% vs. 27,5%; p < 0,001). The previous diagnosis of hypertension did not influence the chance of a patient having his blood pressure measured (p = 0,082). There were no differences between the blood pressure measured by the researchers and those recorded at the medical charts (118 mmHg vs. 117 mmHg; p = 0,651; 72 mmHg vs. 75 mmHg; p = 0,055).
Conclusions: The patients’ blood pressure levels were not measured in many of the medical appointments, especially at outpatient clinics of surgical specialties. (Int J Cardiovasc Sci. 2017;30(4):293-298)

Keywords: Blood Pressure; Outpatient Service; Ambulatory Care; Hypertension; Physician’s Offices.

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12-Month Clinical Follow-Up of Patients Undergoing Early Invasive Strategy by the Transradial or Transfemoral Approach with Vascular Closure Device
Seguimento de 12 Meses de Pacientes Submetidos à Estratégia Intervencionista Precoce pelo Acesso Radial ou Femoral com Dispositivo de Oclusão Vascular

Pedro Beraldo de Andrade, Luiz Alberto Piva e Mattos, Fabio Salerno Rinaldi, Igor Ribeiro de Castro Bienert, Robson Alves Barbosa, Sérgio Kreimer, Vinícius Cardoso Esteves, Marden André Tebet, André Labrunie, Amanda Guerra de Moraes Rego Sousa
International Journal of Cardiovascular Sciences. 2017;30(4):299-306

+   Abstract  
Background: The radial approach reduces the prevalence of vascular complications, major bleeding and mortality when compared to the femoral approach. However, the last still prevails as the preferred approach for the performance of invasive coronary procedures, requiring the adoption of strategies to minimize complications.
Objectives: To compare the survival free of major adverse cardiovascular events at 12 months in patients undergoing early intervention strategy by the radial or femoral access with vascular closure device.
Methods: Randomized non inferiority trial involving 240 non-ST-segment elevation acute coronary syndrome patients. The survival free of death, myocardial infarction or stroke was estimated by the Kaplan-Meier method and compared using the log rank test.
Results: The 30-day rate of vascular complications in the arterial puncture site was 12.5% in the Angio-Seal group and 13.3% in the radial group (p = 1.000). The 12-month incidence of major bleeding or blood transfusion did not differ between groups (2.5% vs. 1.7%, p = 1.000). There was no difference in survival free of major adverse cardiovascular events (90.8% versus 94.2%, p = 0.328).
Conclusions: There was no distinction between the techniques in survival free of major adverse cardiovascular events at 12 months of follow-up. Clinical trials with greater statistical power are needed to validate these findings. (Int J Cardiovasc Sci. 2017;30(4):299-306)
ClinicalTrials.gov Identifier: NCT01653587

Keywords: Myocardial Ischemia; Percutaneous Coronary Percutaneous; Radial Artery; Hemostasis.

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Probabilistic Model for Prediction of Prognostics in Myocardial Revascularization: Complications in Coronary Surgery
Modelo Probabilístico Regional para Avaliação Prognóstica da Cirurgia de Revascularização Miocárdica

Valcellos José da Cruz Viana, Felipe Coelho Argolo, Nilzo Augusto Mendes Ribeiro, Augusto Ferreira da Silva Junior, Luis Claudio Lemos Correia
International Journal of Cardiovascular Sciences. 2017;30(4):307-312

+   Abstract  
Introduction: Risk scores evaluate pre-operatory risk and present support for clinical decisions, however the performance of these tools in samples different from the original ones remains unclear.
Objectives: Investigate the external validity of risk scores (STS and Euroscore) in cardiac surgery and the predictive performance of clinical features derived from the sample.
Methods: Retrospective Cohort study conducted between October, 2010, and April, 2015. We used logistic regression to identify risk factors for hospital morbidity. The sample was divided for cross-validation, with 2/3 of the patients selected for model fitting and 1/3 for prediction testing. The performance of risk scores and clinical features was evaluated through AUROC and calibraton the Hosmer-Lemeshow test (H-L).
Results: Data was retrieved from 472 patients who underwent coronary cardiac surgery in Hospital Santa Izabel da Santa Casa, BA. Mean age was 62.8 years old and 32.5% of the sample were women. Traditional surgical risk scores did not present significant discriminative performance for this sample. Factors associated with the outcome after adjusting for covariates were: age, previous myocardial revascularization and pre-surgical creatinine levels. The adjusted model presented similar discrimination and calibration values during training (AUROC = 0,72; IC 95% 0,59-0,84; H-L valor p: 0,41) and validation (AUROC = 0,70; IC 95% 0,55 - 0,84; H-L valor p: 0,197).
Conclusion: Traditional scores may be inaccurate when applied to different environments. New risk scores with good predictive power can be developed using local clinical variables. (Int J Cardiovasc Sci. 2017;30(4):307-312)

Keywords: Thoracic Surgery/complications; Myocardial Infarction; Myocardial Revascularization; Risk Factors; Forecasting.

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Are Body Fat and Uric Acid Associated with Cardiovascular Risk Scores? Cross-Sectional Analysis in the PROCARDIO-UFV Trial
Gordura Corporal e Ácido Úrico Estão Relacionados com Escores de Risco Cardiovascular? Análise Transversal no Programa de Intervenção PROCADIO-UFV

Juliane Soares Rodrigues, Alinne Paula de Almeida, Carla de Oliveira Barbosa Rosa, Helen Hermana Miranda Hermsdorff
International Journal of Cardiovascular Sciences. 2017;30(4):313-324

+   Abstract  
Background: Risk scores are tools used to indicate the probability of occurrence of a certain cardiovascular event and to previously identify individuals at low, medium, and high risk for the development of cardiovascular diseases.
Objective: To establish the cardiovascular risk of users of a cardiovascular health attention program of a university, and assess its association with lifestyle, clinical, sociodemographic data, and other cardiometabolic risk markers.
Methods: Cross-sectional study with a sample of 197 participants. Demographic, anthropometric, clinical, and metabolic data, eating habits and lifestyle information were collected using the Global Risk Score and the Framingham Risk Score. P-value < 0,05 was considered statistically significant.
Results: According to the Framingham Risk Score, 84% of the assessed population was considered low risk and 16% as intermediate/high risk. However, according to the Global Risk Score, 18% of the participants were low risk, 45% were intermediate risk and 37% were high risk for infarction or death from coronary heart disease in 10 years.
Conclusion: Excess body weight and uric acid serum levels showed to be significant cardiovascular risk markers in addition to those of the score and, consequently, they should be considered in clinical practice. (Int J Cardiovasc Sci. 2017;30(4):313-324)

Keywords: Cardiovascular Diseases/mortality; Obesity; Uric Acid; Life Style; Risk Factors.

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Green Tea Attenuates Hypotension Induced by Physical Exercise: A Randomized, Placebo Controlled Study
Chá Verde Atenua a Hipotensão Induzida por Exercício: Um Estudo Randomizado, Placebo-Controlado

Manoel Miranda Neto, Raquel Suelen Brito da Silva, Taís Feitosa da Silva, Fabiano Ferreira de Lima, Alexandre Sérgio Silva
International Journal of Cardiovascular Sciences. 2017;30(4):325-333

+   Abstract  
Background: Studies have shown that chronic administration of green tea decreases blood pressure (BP) at rest, while a single exercise session also promotes reduction of BP.
Objective: To investigate whether if a single dose of green tea prior to aerobic exercise session improves post-exercise hypotension (PEH).
Methods: Randomized, double-blind, placebo controlled study. Fifteen hypertensive patients (53 ± 3.3 years) participated in two study sessions: green tea+exercise (GTE) and placebo+exercise (PLE). Thirty minutes after ingesting 2 g of green tea or placebo, they performed 60 minutes of treadmill walking at 60 to 85% of maximum heart rate. BP was measured at rest and at every 10 minutes after exercise for 60 minutes. Blood samples were taken before ingestion of green tea or placebo and immediately after exercise to determine malondialdehyde (MDA) and nitrite (NO) concentrations.
Results: On PLE day, systolic PEH was detected at all post-exercise time points (BP reduction by 6.5-11.8 mmHg), whereas on GTE day, PEH was found only at 20 and 40 minutes post-exercise (BP reduction by 5.9 and 5.8 mmHg, respectively). BP reduction was significantly higher in PLE at 10, 20 and 30 minutes post-exercise compared with GTE. In addition, GTE resulted in hypertensive diastolic response, while on PLE day, diastolic PEH was seen only at 20 minutes post-exercise. No changes in MDA or NO concentrations in response to exercise were observed.
Conclusion: Green tea supplementation prior to an aerobic exercise session attenuated systolic PEH and induced diastolic hypertensive response to aerobic exercise in hypertensive patients. (Int J Cardiovasc Sci. 2017;30(4):325-333)

Keywords: Camellia sinensis / drug effects; Hypotension; Exercise; Oxidative Stress; Antioxidants.

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Study of Dabigatran Use in a Brazilian Public Hospital Specialized in Cardiology
Estudo do Uso do Dabigatrana em Hospital Público Brasileiro Especializado em Cardiologia

Luise Barros Martins, Ivis Levy Fernandes Martins, Raíssa Miranda Silva, Flávia Valéria dos Santos Almeida, Christianne Bretas Vieira Scaramello
International Journal of Cardiovascular Sciences. 2017;30(4):334-342

+   Abstract  
Background: During its commercialization phase, unprecedented effects of new medicaments can be discovered. Dabigatran is an anticoagulant approved by Brazilian National Health Surveillance Agency in 2008.
Objectives: To assess safety, effectiveness adverse event profile and adherence to dabigatran (110 mg and 150 mg) prescribed for patients with non-valvular atrial fibrillation.
Methods: Patients taking dabigatran were subjected to interviews during the first year of treatment, evaluating the prescription depending on the dose, age, gender and risk factors as well as the prevalence of adverse events and the profile of the patients involved.
Results: Between the beginning and the end of the study there was a reduction in the number of subjects using this anticoagulant (10% for the dose of 110 mg and 30% for the dose of 150 mg), without changes in the proportions of individuals regarding to gender (men ≅65%), age (age <75 anos ≅80%), anticoagulation previous history (≅85%) and risk scores for thromboembolic (CHA2DS2≥VASc = 2 ≅80%) and bleeding (HASBLED <3 ≅50% dose 110 mg and ≅85% dose 150 mg) events. The most common adverse event was dyspepsia (≥10%), regardless of gender, but less frequently in patients over 75 years of age (≅20% of cases). Dyspepsia related to dabigatran was mainly associated to its combination with beta-blockers (≅70%), but minoritarily with oral hypoglycemic (≅20%), antiplatelet agents (≅10%), proton pump inhibitors (≅30%) and antagonists H2 (≅3%). Therapeutic adherence was ≅60% regardless of the described adverse events. There were no cases of thromboembolic event and major bleeding.
Conclusions: Dabigatran has shown to be safe and effective in the evaluated conditions. (Int J Cardiovasc Sci. 2017;30(4):334-342)

Keywords: Pharmacovigilance; Anticoagulants; Thrombin; Atrial fibrillation.

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REVIEW ARTICLE

Predictors of Metabolic Syndrome in the Elderly: A Review
Preditores de Síndrome Metabólica em Idosos: Uma Revisão

Carolina Cunha de Oliveira, Emanuelle Dias da Costa, Anna Karla Carneiro Roriz, Lilian Barbosa Ramos, Mansueto Gomes Neto
International Journal of Cardiovascular Sciences. 2017;30(4):343-353

+   Abstract  
The article aimed to critically analyse studies which evaluated the capacity of anthropometric and clinical indicators to predict MetS in the elderly. Bibliographical research was performed using the electronic databasese Medline/PubMed, LILACS e SciELO , references from selected articles and contact with several authors. Twenty one articles involving anthropometric and clinical indicators in the elderly were analysed, using different MS criteria. Fourteen studies report anthropometric indicators, being the waist circumference (WC) and waist-to-height ratio (WHtR), described as the best MS predictors, with the area under the ROC curve (AUC) over 0.70 (p < 0.05). The neck circumference was also described as an alternative indicator but with less discriminatory power. Lipid accumulation product (LAP) was the parameter with the best performance to identify MS, with an AUC over 0.85 and efficiency greater than 70%.  The WC, WHtR and LAP indicators were the most sensitive for predicting MS. The use of these parameters may facilitate the early identification of MS, with good accuracy and low cost. In addition, it is important to determine specific cutoff points for the elderly, since obesity alone does not appear to be a strong predictor of MS in the elderly.

Keywords: Aged; Body weights and Measures; Risk Factors; Anthropometry; Obesity; Metabolic Syndrome; Indicators.

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VIEWPOINT

Detailing Peripheral Arterial Tonometry in Heart Failure. An Endothelial Function Evaluation
Função Endotelial e Insuficiência Cardíaca. Começo ou Fim de Uma Disfunção Prestes a Surgir

Aline Cristina Tavares, Edimar Alcides Bocchi, Guilherme Veiga Guimarães
International Journal of Cardiovascular Sciences. 2017;30(4):354-358

+   Introduction  
Endothelium regulates cardiac function and vasomotor tone, adjusts vascular permeability, preserves blood fluidity, playing an important role in cardiovascular homeostasis.1,2 In adults with heart failure (HF), endothelial dysfunction severity is related to diastolic dysfunction,1,2 increase in cardiovascular risk,1-10 heart failure,11,12 exercise incapacity,13 severity of cardiovascular symptoms,6,7,10,14,15 cardiovascular events,16 cardiac transplant and death.17,18
Although endothelium is at the interface between circulating cardiovascular factors and underlying organ tissues, cardiovascular and endothelial peripheral dysfunctions are not totally linked so far.18-20 Evaluation of endothelial function appears as a tempting adjunct for cardiovascular risk stratification,16 and understanding this matter may help having a faster approach and better screening in the cardiomyopathy field in everyday clinical practice, which brings the importance of this paper.
The objective of this study was to perform an interpretation of endothelial function development in HF patients.

Keywords: Endothelium/physiopathology; Heart Failure; Stroke Volume; Nitric Oxide.

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CASE REPORTS

Cardiac Memory, an Underdiagnosed Condition
Memória Cardíaca, um Diagnóstico Esquecido

Margarida Oliveira, Olga Azevedo, Lucy Calvo, Bebiana Faria, Sílvia Ribeiro, António Lourenço
International Journal of Cardiovascular Sciences. 2017;30(4):359-362

+   Introduction  
Cardiac memory, also termed Chatterjee phenomenon, is a known yet uncommonly recognized entity in which myocardial repolarization is altered after abnormal ventricular activation, such as with artificial pacemakers, intermittent left bundle branch block, ventricular premature beats, ventricular pre-excitation or episodes of tachycardia.1 This phenomenon is characterized by persistent but reversible T-wave changes on surface electrocardiogram (ECG) induced by an abnormal electrical activation pattern. The extent and direction of T-wave deviation depend on the duration and direction of abnormal electrical activation and can persist for several weeks. Rosenbaum et al.2 found that the T-wave “resembled” the abnormal QRS vector. The pathophysiology underlying cardiac memory is still complex and evolving, but alterations in the transient outward potassium current — Ito1 — and changes in the phosphorylation status of the cAMP responsive element binding protein (CREB) have been reported.3
Although it seems that cardiac memory is a relatively benign pathophysiologic finding, it may lead to unnecessary and invasive diagnostic investigation if it is not recognized.
Here we report a patient presenting deep T-wave inversion after implantation of cardiac pacemaker.

Keywords: Electrocardiography; Pacemaker Artificial, Pre-Excitation, Mahaim; Myocardial Contraction/physiopathology.

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A Transcatheter Aortic Valve Implantation Without Aortography Guidance Due To Vascular Access Constraints Or Limitations
Implante de Valva Aórtica Transcateter sem Orientação Aortográfica Devido a Limitações de Acesso Vascular

Oktay Ergene, Hamza Duygu, Volkan Emren, Ugur Kocabas, Levent Cerit
International Journal of Cardiovascular Sciences. 2017;30(4):363-366

+   Introduction  
Aortic valve replacement (AVR) is an established treatment modality in patients with severe symptomatic aortic stenosis (AS).1,2 Given the increased mortality and morbidity of AVR for the high-risk patients and the poor long-term results of balloon aortic valvuloplasty, transcatheter aortic valve implantation (TAVI) is increasingly accepted treatment option who are not candidates for AVR.3
We describe here a case of succesfully implanted Edwards SAPIEN XT transcatheter heart valve without aortography guidance due to multiple arterial access problems and complicated by iatrogenic De Bakey type III aortic dissection and severe paravalvular leak.

Keywords: Transcatheter Aortic Valve Replacement; Dissection; Aortic Valve Stenosis.

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